- 专利标题: Apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy
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申请号: US15288840申请日: 2016-10-07
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公开(公告)号: US10004401B2公开(公告)日: 2018-06-26
- 发明人: Ralph Zuckerman
- 申请人: Ivana Ledesma
- 申请人地址: US NY New York
- 专利权人: CELLVIEW IMAGING INC.
- 当前专利权人: CELLVIEW IMAGING INC.
- 当前专利权人地址: US NY New York
- 代理机构: Knobbe, Martens, Olson & Bear, LLP
- 主分类号: G01N1/00
- IPC分类号: G01N1/00 ; A61B5/00 ; A61B5/145 ; A61B5/1455 ; G01N21/64
摘要:
A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.