- 专利标题： Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
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申请号： US15371252申请日： 2016-12-07
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公开(公告)号： US10004743B2公开(公告)日： 2018-06-26
- 发明人: Albert Barta
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim am Rhein
- 代理商 Marc A. Began; Atabak R. Royaee
- 优先权： EP09164659 20090706; EP10154562 20100224
- 主分类号： A61K31/4375
- IPC分类号： A61K31/4375 ; A61K9/00 ; A61K9/28 ; A61K31/517 ; A61K9/16 ; A61K9/20
摘要：
The present invention relates to a drying process of BIBW 2992 or the salts thereof, preferably the dimaleate salt, as well as of solid pharmaceutical formulations comprising BIBW2992 or a salt thereof, and to pharmaceutical compositions comprising BIBW 2992 or a salt thereof as the active product ingredient, characterized by a water activity of the formulation of not more than 0.20 or a water content (Karl-Fischer) of not more than 4.2%.
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