Invention Grant
- Patent Title: Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (TKI)
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Application No.: US14956585Application Date: 2015-12-02
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Publication No.: US10011659B2Publication Date: 2018-07-03
- Inventor: Yosef Yarden , Maicol Mancini , Nadège Gaborit
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; C07K16/32 ; A61K31/506 ; A61K31/517 ; A61K39/395 ; A61N5/10 ; C07K16/40 ; A61K39/00
Abstract:
Methods of treating a subject having cancer exhibiting a resistance to a tyrosine kinase inhibitor (TKI) are provided. Accordingly, there is provided a method comprising administering to the subject a therapeutically effective amount of antibodies comprising an anti-EGFR antibody, an anti-HER2 antibody and an anti-HER3 antibody. Also provided are compositions and articles of manufacture for treating cancer resistance to a TKI. Also provided are methods of treating non-resistant tumors.
Public/Granted literature
- US20160152712A1 COMPOSITIONS AND METHODS FOR TREATING CANCER RESISTANT TO A TYROSINE KINASE INHIBITOR (TKI) Public/Granted day:2016-06-02
Information query
