Implementations relate to automatic response suggestions based on images received in messaging applications. In some implementations, a computer-executed method includes detecting a first image included within a first message received at a second device over a communication network from a first device of a first user, and programmatically analyzing the first image to extract a first image content. The method includes retrieving a first semantic concept associated with the first image content, programmatically generating a suggested response to the first message based on the first semantic concept, and transmitting instructions causing rendering of the suggested response in the messaging application as a suggestion to a second user of the second device.