Provided are an inter-eNodeB communication method and device, wherein the method includes that: an inter-eNodeB interface transmission condition is detected, a cooperation mode of inter-eNodeB communication is determined according to the inter-eNodeB interface transmission condition, and the inter-eNodeB communication is performed according to the cooperation mode. The present disclosure solves the problem of inter-eNodeB cooperation in different inter-eNodeB interface conditions in the related art, thus improving the effect of the inter-eNodeB cooperation.