![Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors](/docs/US/2018-07-31/US10035800B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors
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Application No.: US14774866Application Date: 2014-03-12
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Publication No.: US10035800B2Publication Date: 2018-07-31
- Inventor: Steven D. Fidanze , Dauchun Liu , Robert A. Mantei , Keith F. McDaniel , John Pratt , George S. Sheppard , Le Wang , Andrew Bogdan , James H. Holms , Justin D. Dietrich , Jasmina Marjanovic , Lisa A. Hasvold , Yujia Dai
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agent Michael S. Montgomery
- International Application: PCT/CN2014/000258 WO 20140312
- International Announcement: WO2014/139324 WO 20140918
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D471/22 ; C07D471/16
![Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors](/abs-image/US/2018/07/31/US10035800B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y3, A1, A2, A3 and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
Public/Granted literature
- US20160039821A1 TETRACYCLIC BROMODOMAIN INHIBITORS Public/Granted day:2016-02-11
Information query
IPC分类:
