The present technology provides a heavy duty pneumatic tire with a tread portion having a tread pattern including: a pair of circumferential primary grooves defined in a wave-like shape and extending in the tire circumferential direction; center lug grooves; center blocks; and circumferential secondary grooves extending in regions of the center blocks and open to the center lug grooves. The center lug grooves have two groove turning portions turned in a bend shape or a curved shape. The circumferential secondary grooves extend in an inclined manner relative to the tire circumferential direction. An inclination angle (θ4) of the circumferential secondary grooves relative to the tire circumferential direction is different from an inclination angle (θ1) of portions of the circumferential primary grooves relative to the tire circumferential direction, the portions extending toward the same side as a side in the tire width direction, toward which the circumferential secondary grooves are inclined.