Hardware-based translation lookaside buffer (TLB) invalidation techniques are disclosed. A host system is configured to exchange data with a peripheral component interconnect express PCIE) endpoint (EP). A memory management unit (MMU), which is a hardware element, is included in the host system to provide address translation according to at least one TLB. In one aspect, the MMU is configured to invalidate the at least one TLB in response to receiving at least one TLB invalidation command from the PCIE EP. In another aspect, the PCIE EP is configured to determine that the at least one TLB needs to be invalidated and provide the TLB invalidation command to invalidate the at least one TLB. By implementing hardware-based TLB invalidation in the host system, it is possible to reduce TLB invalidation delay, thus leading to increased data throughput, reduced power consumption, and improved user experience.