Invention Grant
- Patent Title: Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-CoA and bacteria expressing same
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Application No.: US15101097Application Date: 2014-12-10
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Publication No.: US10053712B2Publication Date: 2018-08-21
- Inventor: Arren Bar-Even , Ron Milo , Elad Noor , Lior Zelcbuch
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- International Application: PCT/IL2014/051080 WO 20141210
- International Announcement: WO2015/087327 WO 20150618
- Main IPC: C12P7/40
- IPC: C12P7/40 ; C12N1/20 ; C12N9/10 ; C12N15/52 ; C12P5/00 ; C12P5/02 ; C12P7/06 ; C12P7/16 ; C12P7/26 ; C12P7/64
Abstract:
An isolated microorganism is disclosed being genetically modified to express pyruvate formate lyase (PFL) or 2-ketobutyrate formate lyase, wherein acetyl-CoA of the microorganism is converted to pyruvate in the presence of formate in a single step reaction, wherein the net flux of the reaction is in the direction of pyruvate synthesis.Uses of the microorganism and products comprising same are also disclosed.
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