Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for pre-fetching data. The methods, systems, and apparatus include actions of providing a request for data to an input-output device and receiving a set of memory addresses for the requested data. Additional actions include determining a subset of the memory addresses, providing a request for a processor to pre-fetch or inject data corresponding to the subset of the memory addresses, and receiving the requested data and the set of memory addresses. Additional actions include determining that the received data includes data for the subset of memory addresses that has been requested to be pre-fetched or injected, storing the data for the subset of memory addresses in a cache of the processor, and storing remaining data of the received data for the memory addresses in a main memory.