Invention Grant
- Patent Title: Antidiabetic compounds
-
Application No.: US15110894Application Date: 2015-02-03
-
Publication No.: US10059667B2Publication Date: 2018-08-28
- Inventor: Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Cangming Yang
- Applicant: MERCK SHARP & DOHME CORP. , Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Cangming Yang , Rui Zhang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2015/014153 WO 20150203
- International Announcement: WO2015/119899 WO 20150813
- Main IPC: C07D211/42
- IPC: C07D211/42 ; A61K45/06 ; A61K31/366 ; A61K31/397 ; A61K31/40 ; A61K31/44 ; C07D231/20 ; A61K31/4985 ; C07D401/04 ; C07D239/52 ; C07C217/52 ; C07D205/04 ; C07D491/056 ; C07D265/30 ; C07D207/08 ; C07D207/10 ; C07D207/12 ; C07D209/52 ; C07D209/54 ; C07D211/22 ; C07D213/30 ; C07D213/64 ; C07D213/65 ; C07D213/69 ; C07D307/86 ; C07D307/88 ; C07C59/72 ; C07D205/12 ; C07D213/647

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US20160332968A1 ANTIDIABETIC COMPOUNDS Public/Granted day:2016-11-17
Information query