- 专利标题： Therapeutic targeting of the interleukin 1 receptor-associated kinase 4 (IRAK4) in leukemias characterized by rearrangements in the mixed lineage leukemia gene (MLL-r)
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申请号： US15497783申请日： 2017-04-26
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公开(公告)号： US10059708B2公开(公告)日： 2018-08-28
- 发明人: Ali Shilatifard , Kaiwei Liang , Edwin Richard Smith
- 申请人： Northwestern University
- 申请人地址： US IL Evanston
- 专利权人： Northwestern University
- 当前专利权人： Northwestern University
- 当前专利权人地址： US IL Evanston
- 代理机构： Andrus Intellectual Property Law, LLP
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D233/88
摘要：
Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4).
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