A valve including a valve housing through which a process medium can flow and in which a valve seat is located, which surrounds a through-flow opening and to which a valve member mounted on a spindle is assigned in such a way that the valve member can be moved by means of an actuating stroke of the spindle between a blocking position in which the valve member bears against the valve seat in a process medium-tight manner and an open position in which the valve member is raised off the valve seat, and wherein an interface for coupling a drive unit generating the actuating stroke of the spindle is provided on the valve housing, and wherein a sealing device through which the spindle passes is accommodated in the valve housing, the sealing device is accommodated in a seal cartridge which is separate from the valve housing and configured as an operational pre-assembly.