Methods of well treatment include modeling approaches that account for the effect of pore structure during well stimulation treatments. In one aspect, methods may include preparing a computer model of a porous medium; simulating an injection of a fluid into the computer model of the porous medium; measuring a pore-scale heterogeneity of the computer model of the porous medium, and designing a stimulating fluid treatment for the porous medium. Other aspects may include the development of a wellbore stimulation methodology that allows stimulation fluid breakthrough curves of differing formation samples to be plotted as a single curve that accounts for the varied pore structure of the respective samples.