Operand liveness state information is maintained during context switches for current architected operands of executing programs. The current operand state information indicates whether corresponding current operands are enabled or disabled for use by a first program module comprising machine instructions of an instruction set architecture (ISA) for disabling current architected operands. A machine instruction of the first program module accesses a current operand by using the current operand state information to determine whether a previously stored current operand value is accessible by the first program module.