A method of base station (BS) in a wireless communication system. the method comprises identifying a set of transmission parameters comprising a numerology, wherein the numerology includes a subcarrier spacing, determining a plurality of baseband signal generation chains each of which includes the set of transmission parameters comprising different numerology, and transmitting, at least one user equipment (UE), downlink signals comprising the set of transmission parameters using a multi-user multi-input multi-output (MU-MIMO).