Invention Grant
- Patent Title: Diagnosis of benign and cancerous growths by measuring circulating tumor stem cells and serum AnnexinA2
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Application No.: US15408886Application Date: 2017-01-18
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Publication No.: US10067134B2Publication Date: 2018-09-04
- Inventor: Pomila Singh
- Applicant: The Board of Regents of the University of Texas System
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Mueting, Raasch & Gebhardt, P.A.
- Main IPC: G01N33/574
- IPC: G01N33/574
Abstract:
Provided herein is a method for diagnosing/prognosing a metastatic cancer in a subject by measuring and detecting one or more of CS-ANXA2, DCAMKL, Lgr5 or CS-ANAX2 and DCAMKL or CS-ANXA2 and Lgr5 positive circulating tumor stem cells in the subject's blood or plasma. Also provided is a method for distinguishing the presence of early stage primary cancer from advanced stage metastatic cancer in the subject by measuring and detecting AnnexinA2, CS-ANXA2 and DCAMKL-1 or Lgr5 in the blood or plasma. In addition, there is provided a method for distinguishing the presence of benign, pre-cancerous tumorous growths or cancerous tumors in the subject by measuring and detecting AnnexinA2 and circulating tumor stem cells positive for CS-ANXA2 and DCAMKL or CS-ANXA2 and Lgr5 in the blood or plasma.
Public/Granted literature
- US20170122952A1 DIAGNOSIS OF BENIGN AND CANCEROUS GROWTHS BY MEASURING CIRCULATING TUMOR CELLS AND SERUM ANNEXINA 2 Public/Granted day:2017-05-04
Information query
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