A USB charging device is disclosed, comprising a charging base and multiple USB chargers, in which the surface of the charging base is installed with several positioning slots and the bottom of the positioning slot has DC power output holes. In addition, the bottom of the USB charger is configured with a fixation bump fitting into the shape of the fixation slot, and conductive pillars extend from the fixation bump, while the other end of the USB charger includes a USB port for electrically connecting to a USB charging line. Herein the conductive pillars of the USB charger can be inserted into any one of the positioning DC output holes on the surface of the charging base such that DC power can be transferred to the USB port and thus further transferred to the electronic device via the USB charging line for power recharging.