Methods and apparatus to configure virtual private mobile networks are disclosed. Example methods include provisioning a virtual private mobile network within a wireless network, and, after provisioning the virtual private mobile network, determining whether a first communication from a user equipment matches a security event profile. When the first communication matches the profile, the example methods include transmitting, from the wireless network via a first base transceiver station, an instruction to cause the user equipment to be communicatively coupled to the virtual private mobile network. The example methods further include instructing the user equipment to transmit a second communication through a second base transceiver station that is physically separate from the first base transceiver station and through the virtual private mobile network. In the example methods, the virtual private mobile network is isolated in a wireless spectrum from other portions of the network.