Methods, apparatus, systems and articles of manufacture are disclosed to facilitate multi-factor authentication policy enforcement using one or more policy handlers. An example first policy handler to manage a global policy in a distributed environment includes a parser to identify a first sub-policy of the global policy that is capable of enforcement by the first policy handler, and an attester to sign the first sub-policy. The example first policy handler further includes a director to determine whether to forward the global policy to a second policy handler based on a signature status of the global policy, and to forward the global policy to the second policy handler when the signature status of the global policy is indicative of an unsigned second sub-policy.