- 专利标题： Vector comprising multiple homologous nucleotide sequences
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申请号： US15399588申请日： 2017-01-05
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公开(公告)号： US10072274B2公开(公告)日： 2018-09-11
- 发明人: Robin Steigerwald
- 申请人： BAVARIAN NORDIC A/S
- 申请人地址： DK Kvistgaard
- 专利权人： BAVARIAN NORDIC A/S
- 当前专利权人： BAVARIAN NORDIC A/S
- 当前专利权人地址： DK Kvistgaard
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N15/863
摘要：
The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further relates to nucleotide sequences containing substituted bases.
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