- 专利标题： Methods and compositions for the diagnosis and treatment of cancer
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申请号： US14869724申请日： 2015-09-29
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公开(公告)号： US10073100B2公开(公告)日： 2018-09-11
- 发明人: Rui Xing , Youyong Lu , Zhibo Gao , Wenmei Li , Jiantao Cui , Lin Li , Longyun Chen
- 申请人： BGI Tech Solutions Co., Ltd , Beijing Institute For Cancer Research
- 申请人地址： CN Guangdong CN Beijing
- 专利权人： BGI TECH SOLUTIONS CO., LTD,BEIJING INSTITUTE FOR CANCER RESEARCH
- 当前专利权人： BGI TECH SOLUTIONS CO., LTD,BEIJING INSTITUTE FOR CANCER RESEARCH
- 当前专利权人地址： CN Guangdong CN Beijing
- 代理机构： Alston & Bird LLP
- 优先权： CN201410512479 20140929
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/574 ; C12Q1/6886 ; C07K16/28
摘要：
The present invention relates to methods, kits, and compositions for detecting and/or diagnosing metastatic potential of cancer cells or for evaluating prognosis in a patient with cancer by detection of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule. The present invention also relates to the use of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule as a prognosis biomarker and metastasis predictive biomarker of cancer.
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