- 专利标题： Isoxazole derivatives as FXR agonists and methods of use thereof
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申请号： US15497307申请日： 2017-04-26
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公开(公告)号： US10080742B2公开(公告)日： 2018-09-25
- 发明人: Yat Sun Or , Ruichao Shen , Xuechao Xing , Brett Granger , Bin Wang , Jun Ma , Jing He , Yong He , Jiang Long , Guoqiang Wang
- 申请人： Enanta Pharmaceuticals, Inc.
- 申请人地址： US MA Watertown
- 专利权人： Enanta Pharmaceuticals, Inc.
- 当前专利权人： Enanta Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Watertown
- 代理机构： Elmore Patent Law Group, PC
- 代理商 Edgar Harlan; Carolyn Elmore
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; C07D413/12 ; C07D413/14 ; A61K31/42 ; A61K31/426 ; A61K31/4725 ; A61K31/545 ; A61K31/64 ; C07D261/08 ; C07D275/04 ; C07D277/62
摘要：
The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated as FXR modulators. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.
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