Invention Grant
- Patent Title: Diamide macrocycles that are FXIa inhibitors
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Application No.: US15508122Application Date: 2015-09-03
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Publication No.: US10081623B2Publication Date: 2018-09-25
- Inventor: Jun Shi , William R. Ewing , Laura Nielsen , Zilun Hu , Mimi L. Quan
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2015/048212 WO 20150903
- International Announcement: WO2016/036893 WO 20160310
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D403/06 ; C07D403/12 ; C07D409/12 ; C07D401/12

Abstract:
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20170283403A1 DIAMIDE MACROCYCLES THAT ARE FXIA INHIBITORS Public/Granted day:2017-10-05
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