Invention Grant
- Patent Title: Affinity maturated T cell receptors and use thereof
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Application No.: US13958277Application Date: 2013-08-02
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Publication No.: US10081663B2Publication Date: 2018-09-25
- Inventor: Lea Eisenbach , Yosi Gozlan , Esther Tzehoval
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co., Ltd.
- Current Assignee: Yeda Research and Development Co., Ltd.
- Current Assignee Address: IL Rehovot
- Main IPC: C12N15/12
- IPC: C12N15/12 ; C12N15/63 ; C12N15/85 ; C12N5/16 ; C07K14/705 ; C07K14/725 ; C12N15/10 ; A61K35/17
Abstract:
The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
Public/Granted literature
- US20140065111A1 Affinity Maturated T Cell Receptors And Use Thereof Public/Granted day:2014-03-06
Information query
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