An oil filter layout structure for an internal combustion engine for a motorcycle. An exhaust pipe connected to an exhaust port extends rearwardly beneath the internal combustion engine along a longitudinal direction of the motorcycle. An oil pan is disposed below the internal combustion engine, the oil pan having one of left and right side walls spaced along a transverse direction of the motorcycle. The one side wall is inclined downwardly toward a center of the motorcycle. The exhaust pipe is disposed closely to the side wall. An oil filter is mounted on the internal combustion engine and disposed below the internal combustion engine in overlapping relation to the oil pan as viewed in side elevation, near the other of the left and right side walls of the oil pan.