System and method for controlling test flow of a radio frequency (RF) signal transceiver device under test (DUT) by inducing an interrupt via an internal signal interface or an external signal interface (with one example of the latter being a baseband signal interface for conveying audio signals). With exemplary embodiments, one or more DUT control signals are provided to or otherwise initiated within the DUT by inducing an interrupt, including inducement via use of the signal interface. With further exemplary embodiments, one or more test control signals are also provided to RF circuitry that responds by transmitting one or more RF receive signals for the DUT and receives from the DUT one or more RF transmit signals related to the one or more DUT control signals.