Methods and systems are provided for automated tube current modulation (ATCM). In one embodiment, a method for an imaging system comprises: calculating a desired dose level based on a clinical task, a size of a subject to be scanned, and an image quality level; generating a scan protocol based on a relation between the image quality level and at least one characteristic of the imaging system; and performing a scan of the subject at the desired dose level and according to the generated scan protocol. In this way, ATCM can be optimized based on elements that impact image quality such as the clinical task, the physical characteristics of the imaging system, the individual patient, and the reader's preference.