Invention Grant
- Patent Title: Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties
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Application No.: US15341573Application Date: 2016-11-02
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Publication No.: US10087211B2Publication Date: 2018-10-02
- Inventor: Scott P. Runyon , Michael Rogawski , Edgar Cook , John Kepler , Hernan Navarro , Rafal Kaminski , Matthew Orr
- Applicant: RESEARCH TRIANGLE INSTITUTE , The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US NC Research Triangle Park US DC Washington
- Assignee: RESEARCH TRIANGLE INSTITUTE,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: RESEARCH TRIANGLE INSTITUTE,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US NC Research Triangle Park US DC Washington
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Main IPC: C07J7/00
- IPC: C07J7/00 ; C07J41/00 ; C07J31/00
Abstract:
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
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