A variety of methods and arrangements for detecting misfire and other engine-related errors are described. In one aspect, a window is assigned to a target firing opportunity for a target working chamber. There is an attempt to fire a target working chamber during the target firing opportunity. A change in an engine parameter (e.g., crankshaft angular acceleration) is measured during the window. A model (e.g., a pressure model) is used to help determine an expected change in the engine parameter during the target firing opportunity. Based on a comparison of the expected change and the measured change in the engine parameter, a determination is made as to whether an engine error (e.g., misfire) has occurred.