A detection system for a locomotive may include a plurality of sensors. An electronic control module may be in communication with, at least, the plurality of sensors and the locomotive. The control module may be configured to: monitor the plurality of sensors; receive an alert from one of the sensors of the plurality of sensors when one of the corresponding sensors is triggered; determine if the alert is a security concern; and operatively respond to the security concern by at least one of removing tractive effort to the locomotive, apply braking force to the locomotive, locking a door of the locomotive, locking a window of the locomotive, and transmitting a notification.