![Crystalline forms of (2R,5S,13AR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13A- octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-B] [1,3] oxazepine-10-carboxamide](/docs/US/2018-10-16/US10098886B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline forms of (2R,5S,13AR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13A- octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-B] [1,3] oxazepine-10-carboxamide
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Application No.: US15588346Application Date: 2017-05-05
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Publication No.: US10098886B2Publication Date: 2018-10-16
- Inventor: Ernest A. Carra , Irene Chen , Katie Ann Keaton , Scott E. Lazerwith , Vahid Zia
- Applicant: Gilead Sciences, Inc.
- Applicant Address: US CA Foster City
- Assignee: GILEAD SCIENCES, INC.
- Current Assignee: GILEAD SCIENCES, INC.
- Current Assignee Address: US CA Foster City
- Main IPC: C07D498/18
- IPC: C07D498/18 ; A61K31/5365 ; A61K45/06 ; A61K9/20 ; C07D498/14 ; A61K31/513 ; A61K31/553 ; A61K31/675 ; A61K31/683 ; A61K31/537
![Crystalline forms of (2R,5S,13AR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13A- octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-B] [1,3] oxazepine-10-carboxamide](/abs-image/US/2018/10/16/US10098886B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.
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