Systems and methods for uniformly expanding and heat setting medical devices. One method can include expanding a medical device by advancing the medical device over a preheated expander, the medical device being uniformly expanded as the medical device is advanced over the preheated expander; and heat setting the expanded medical device while the medical device is positioned over the expander, the preheated expander being maintained at a predetermined heat-setting temperature. The preheated expander can be positioned within a thermal chamber that maintains the preheated expander at the predetermined heat-setting temperature. The medical device can be physically separated from the preheated expander when the medical device is positioned over the expander and can be comprised of a shape-memory material. The preheated expander can remain heated during the expansion and heat setting of a plurality of medical devices.