The present disclosure relates to a method for characterizing a hydrocarbon reservoir of interest traversed by at least one wellbore that includes (a) using a numerical model to simulate over geological time a non-equilibrium concentration of an asphaltene component as a function of location within the wellbore, (b) analyzing fluid samples acquired from at least one wellbore that traverses the reservoir of interest to measure concentration of the asphaltene component as a function of location within the wellbore, (c) comparing the non-equilibrium concentration of the asphaltene component as a function of location within the wellbore resulting from the simulation of (a) to the concentration of the asphaltene component as a function of location within the wellbore as measured in (b), and characterizing the reservoir of interest based upon the comparing of (c).