- 专利标题： Potent dual BRD4-kinase inhibitors as cancer therapeutics
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申请号： US15501613申请日： 2015-08-03
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公开(公告)号： US10106507B2公开(公告)日： 2018-10-23
- 发明人: Ernst Shönbrunn , Nicholas J. Lawrence , Harshani R. Lawrence
- 申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
- 申请人地址： US FL Tampa
- 专利权人： H. Lee Moffitt Cancer Center and Research Insitute, Inc.
- 当前专利权人： H. Lee Moffitt Cancer Center and Research Insitute, Inc.
- 当前专利权人地址： US FL Tampa
- 代理机构： Meunier Carlin & Curfman LLC
- 国际申请： PCT/US2015/043389 WO 20150803
- 国际公布： WO2016/022460 WO 20160211
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; A61K31/505 ; A61K45/06 ; A61K31/506 ; A61K31/5377 ; C07D405/12 ; C07D239/95 ; A61K31/517 ; C07D239/70 ; C07D491/048 ; A61K31/519 ; C07D401/12 ; C07D403/12 ; C07D401/14
摘要：
Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
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