Invention Grant
- Patent Title: Process and intermediates for making tubulysin analogs
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Application No.: US15623570Application Date: 2017-06-15
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Publication No.: US10106560B2Publication Date: 2018-10-23
- Inventor: Adrian Ortiz , Carlos A. Guerrero , Bin Zheng , Jason J. Zhu , Michael Anthony Schmidt , Michael R. Luzung , Martin D. Eastgate
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07F7/18 ; C07D211/28 ; C07F7/08
Abstract:
An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.
Public/Granted literature
- US20170362259A1 PROCESS AND INTERMEDIATES FOR MAKING TUBULYSIN ANALOGS Public/Granted day:2017-12-21
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