- 专利标题： Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B
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申请号： US14771448申请日： 2014-02-27
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公开(公告)号： US10125094B2公开(公告)日： 2018-11-13
- 发明人: Koen Vandyck , Stefaan Julien Last , Pierre Jean-Marie Bernard Raboisson
- 申请人： Janssen Sciences Ireland UC
- 申请人地址： IE Little Island, County Cork
- 专利权人： Janssen Sciences Ireland UC
- 当前专利权人： Janssen Sciences Ireland UC
- 当前专利权人地址： IE Little Island, County Cork
- 优先权： EP13157232 20130228; EP13170069 20130531
- 国际申请： PCT/EP2014/053858 WO 20140227
- 国际公布： WO2014/131847 WO 20140904
- 主分类号： C07C311/37
- IPC分类号： C07C311/37 ; A61K31/18 ; C07C311/16 ; C07C311/17 ; C07C311/18 ; C07C311/19 ; C07C317/28 ; A61K45/06 ; A61K31/27 ; A61K31/277
摘要：
Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, salts, hydrates and solvates thereof, wherein R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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