- 专利标题： KRas G12C inhibitors
-
申请号： US15814279申请日： 2017-11-15
-
公开(公告)号： US10125134B2公开(公告)日： 2018-11-13
- 发明人: James F. Blake , Laurence E. Burgess , Mark Joseph Chicarelli , James Gail Christensen , Jay Bradford Fell , John P. Fischer , John J. Gaudino , Erik James Hicken , Ronald Jay Hinklin , Matthew Randolf Lee , Matthew Arnold Marx , Macedonio J. Mejia , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P. A. Vigers , Henry J. Zecca
- 申请人： Mirati Therapeutics, Inc. , Array BioPharma Inc.
- 申请人地址： US CA San Diego US CO Boulder
- 专利权人： MIRATI THERAPEUTICS, INC.,ARRAY BIOPHARMA INC.
- 当前专利权人： MIRATI THERAPEUTICS, INC.,ARRAY BIOPHARMA INC.
- 当前专利权人地址： US CA San Diego US CO Boulder
- 代理机构： Wood, Phillips, Katz, Clark & Mortimer
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D519/00 ; A61K31/519
摘要：
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
公开/授权文献
- US20180072723A1 KRAS G12C INHIBITORS 公开/授权日：2018-03-15
信息查询
