Multi-layer configurable timing switch fabrics and related methods are disclosed for selectively distributing multiple timing sources to multiple timing consumers. Configurable timing switches are used at central and multiple local levels within the housing for a network-connected processing system to selectively distribute the timing sources to the timing consumers. As such, significant flexibility is provided with respect to what timing sources can be received within the system and how these timing sources are distributed to different timing consumers. Further, timing information can be generated within the network-connected processing system based upon network communications received from timing consumers, and this generated timing information can also be used as timing sources for the multi-layer configurable timing switch fabric.