A capsule endoscope for photodynamic and sonodynamic therapy is disclosed. The capsule includes: an endoscope body; a light and ultrasonic wave irradiation portion provided on the outer surface of the endoscope body and irradiating light of different wavelengths and ultrasonic waves; and a photodynamic and sonodynamic therapy portion connected to the outer surface of the endoscope body and comprising a material for photodynamic and sonodynamic therapy, wherein the photodynamic and sonodynamic therapy portion can be activated by the light and ultrasonic waves irradiated from the light and ultrasonic wave irradiation portion. The capsule endoscope can treat local bacterial infection, or diabetes, malignant diseases, chronic colitis and the like caused by a change in the number and type of intestinal floras while passing through the body in addition to carrying out diagnosis, which is the inherent function of a capsule endoscope, and thus there is no need for additional treatment and a patient can comfortably receive therapy.