- 专利标题： Poly((lactic-co-glycolic acid)-B-lysine) and process for synthesizing a block copolymer of PLGA {poly(lactic-co-glycolic acid)} and PLL (poly-ϵ-cbz-L-lysine)
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申请号： US14232525申请日： 2012-07-13
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公开(公告)号： US10131786B2公开(公告)日： 2018-11-20
- 发明人: John Harvey , Daniel Siegwart , Heng Lian Huang , Brian Hess , Alex Aimetti
- 申请人： John Harvey , Daniel Siegwart , Heng Lian Huang , Brian Hess , Alex Aimetti
- 申请人地址： US MA Cambridge US MA Cambridge
- 专利权人： INVIVO THERAPEUTICS CORPORATION,MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人： INVIVO THERAPEUTICS CORPORATION,MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： US MA Cambridge US MA Cambridge
- 代理机构： Pierce Atwood LLP
- 代理商 Raymond G. Arner
- 国际申请： PCT/US2012/046687 WO 20120713
- 国际公布： WO2013/010087 WO 20130117
- 主分类号： C08G81/00
- IPC分类号： C08G81/00 ; C08L67/08 ; A61K47/42 ; C08G63/08 ; C08L101/16 ; C08G69/08 ; C08G69/10 ; C08G69/48 ; C08L77/04 ; A61K47/34
摘要：
A method of synthesizing copolymers is provided. The method can include coupling a degradable polymer to a poly(amino acid) and then deprotecting the copolymer if the poly(amino acid) contains protected side chains. Copolymer compositions are provided. These compositions include PLGA-PLL copolymers, PLGA-PLL-cbz copolymers, and copolymers of a polyester with a carboxylic acid end group coupled to a poly(amino acid) with an amine group. The compositions may include therapeutic blends and formulations of copolymers.