The present invention provides a hot-dip galvanized steel sheet that is excellent in plating wettability and plating adhesiveness even when a base steel sheet contains Si and Mn, and a manufacturing method of the same. The hot-dip galvanized steel sheet according to the present invention includes a base steel sheet containing Si, Mn, and other predetermined components, and a hot-dip galvanizing layer formed on at least one surface of the base steel sheet. In the base steel sheet, a value of HA representing average hardness in a surface layer ranging from an interface between the base steel sheet and the hot-dip galvanizing layer to 50 μm in depth and a value of HB representing average hardness in a deep portion ranging from the interface to greater than 50 μm in depth satisfy all the following three relational expressions. 50≤HA≤500  (1) 50≤HB≤500  (2) 0.5≤HA/HB≤0.9  (3)