Systems and associated methods for reciprocity calibration of multiple-input multiple-output (MIMO) wireless communication are disclosed herein. In one embodiment, a method for reciprocity calibration of the MIMO system includes transmitting a pilot symbol by a transmitter (TX) of the reference antenna and receiving the pilot symbol by receivers (RXes) of antennas of a base station as ri,0 pilot symbols. (Index “i” denotes individual antenna “i” of the base station, and “0” denotes the reference antenna.) The method further includes transmitting the received pilot symbols by TXes of the antennas of the base station, receiving the pilot symbols transmitted by the antennas of the base station by the reference antenna as r0,i pilot symbols, and calculating non-reciprocity compensation factors as r i , 0 r 0 , i .