发明授权
- 专利标题： Methods and compositions for expanding long-term hematopoietic stem cell populations
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申请号： US14903548申请日： 2014-07-14
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公开(公告)号： US10137154B2公开(公告)日： 2018-11-27
- 发明人: Daohong Zhou , Yi Luo , Lijian Shao , Wei Feng , Jianhui Chang
- 申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , Daohong Zhou , Yi Luo , Lijian Shao , Wei Feng , Jianhui Chang
- 申请人地址： US AR Little Rock
- 专利权人： BioVentures, LLC
- 当前专利权人： BioVentures, LLC
- 当前专利权人地址： US AR Little Rock
- 代理机构： Polsinelli PC
- 国际申请： PCT/US2014/046498 WO 20140714
- 国际公布： WO2015/006762 WO 20150115
- 主分类号： A61K35/28
- IPC分类号： A61K35/28 ; C12N5/0789 ; A61K35/15 ; A61K35/12
摘要：
The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.