- 专利标题： Factor XIa inhibitors
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申请号： US15681478申请日： 2017-08-21
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公开(公告)号： US10143681B2公开(公告)日： 2018-12-04
- 发明人: Dong-Ming Shen , Rongze Kuang , Puneet Kumar , Joseph L. Duffy , Cheng Zhu , Amjad Ali , Meng Yang , John S. Debenham
- 申请人： MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Nicole M. Beeler; John C. Todaro
- 主分类号： A61K31/4412
- IPC分类号： A61K31/4412 ; C07D213/89 ; A61K31/435
摘要：
The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
公开/授权文献
- US20180050022A1 FACTOR XIa INHIBITORS 公开/授权日：2018-02-22
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