- 专利标题： Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs, methods of making and use thereof
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申请号： US15812730申请日： 2017-11-14
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公开(公告)号： US10144740B2公开(公告)日： 2018-12-04
- 发明人: Travis Mickle , Sven Guenther , Sanjib Bera , Bindu Bera , Jaroslaw Kanski , Andrea Martin
- 申请人： KemPharm, Inc
- 申请人地址： US IA Coralville
- 专利权人： KemPharm, Inc.
- 当前专利权人： KemPharm, Inc.
- 当前专利权人地址： US IA Coralville
- 代理机构： McAndrews, Held & Malloy, Ltd.
- 代理商 Robert Hoag
- 主分类号： C07D489/04
- IPC分类号： C07D489/04 ; C07D498/08 ; A61P25/36
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone (4,5-α-epoxy-14-hydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxycodone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxycodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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