In accordance with the present invention, there are provided systems and methods for contacting two or more fluids, useful, for example for purifying or infusing a fluid (by allowing efficient and/or uniform addition of components to or removal of components from the fluid). The components may be undesirable components to be removed from a fluid, or a desired component or components to be added to the fluid, for example, each of which is referred to herein as “component”. In this regard, the disclosed embodiments provide for the purification or infusion of a fluid by passing a liquid and a fluid through a contacting zone which facilitates intimate mixing of the liquid and the fluid. A differential of partial pressure, activity, fugacity or concentration of the components between the liquid and the fluid facilitates the transfer of the components between the liquid and the fluid in the intimately mixed liquid and fluid.