- 专利标题: Recombinant monovalent antibodies and methods for production thereof
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申请号: US12095023申请日: 2006-11-28
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公开(公告)号: US10155816B2公开(公告)日: 2018-12-18
- 发明人: Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
- 申请人: Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
- 申请人地址: DK Copenhagen V
- 专利权人: GENMAB A/S
- 当前专利权人: GENMAB A/S
- 当前专利权人地址: DK Copenhagen V
- 代理机构: Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Christopher L. Frank
- 国际申请: PCT/DK2006/000669 WO 20061128
- 国际公布: WO2007/059782 WO 20070531
- 主分类号: C07K16/18
- IPC分类号: C07K16/18 ; C07K19/00 ; C07K16/28
摘要:
The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.