- 专利标题： Antibodies against CD73
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申请号： US15432180申请日： 2017-02-14
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公开(公告)号： US10167343B2公开(公告)日： 2019-01-01
- 发明人: Nils Lonberg , Alan J. Korman , Bryan C. Barnhart , Aaron P. Yamniuk , Mohan Srinivasan , Karla A. Henning , Ming Lei , Emanuela Sega , Angela Goodenough , Maria N. Jure-Kunkel , Guodong Chen , John S. Sack , Richard Y. Huang , Martin J. Corbett , Joseph E. Myers, Jr. , Liang Schweizer , Sandra V. Hatcher , Haichun Huang , Pingping Zhang
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： US NJ Princeton
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Jeanne M. DiGiorgio, Esq.
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; C07K16/40 ; A61K39/00 ; A61K39/395 ; A61K45/06 ; G01N33/573 ; C07K16/28
摘要：
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
公开/授权文献
- US20170253665A1 ANTIBODIES AGAINST CD73 公开/授权日：2017-09-07
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