发明授权
- 专利标题： Methods and compositions for inhibiting the interaction of menin with MLL proteins
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申请号： US16014996申请日： 2018-06-21
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公开(公告)号： US10174041B2公开(公告)日： 2019-01-08
- 发明人: Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jonathan Pollock , Liansheng Li , Tao Wu , Jun Feng , Pingda Ren , Yi Liu , Szymon Klossowski
- 申请人： Kura Oncology, Inc. , The Regents of The University of Michigan
- 申请人地址： US CA San Diego US MI Ann Arbor
- 专利权人： Kura Oncology, Inc.,The Regents of The University of Michigan
- 当前专利权人： Kura Oncology, Inc.,The Regents of The University of Michigan
- 当前专利权人地址： US CA San Diego US MI Ann Arbor
- 代理机构： Wilson Sonsini Goodrich & Rosati
- 优先权： ARP20160100689 20160315
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D519/00 ; C07D513/04 ; C07D498/04 ; C07D495/04 ; C07D491/048 ; C07D473/34
摘要：
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.
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